NASA 1998 SBIR Phase I


PROPOSAL NUMBER: 98-1 09.02-7770A

PROJECT TITLE: Immobilized Antimicrobials for Enhanced Control of Bacterial Contamination

TECHNICAL ABSTRACT (LIMIT 200 WORDS)

Improved methods for control of microbial growth are required to support long duration manned missions. To further this aim, an investigation of the use of immobilized antibiotics and enzymes is proposed. Potential areas of application of these materials include: control of surface populations (particularly in food preparation and personal hygiene areas, i.e., shower, urinal and commode), prevention of microbial colonization and decomposition of materials of construction, prevention of biofilm formation, treatment of hydroponic solutions, potentiation of chemical drinking water disinfection, endotoxin removal from aqueous streams, enhanced microbial control for biological experimentation, and control of airborne human and plant pathogens. Preliminary experimentation has demonstrated destruction of gram positive and gram negative bacteria in aqueous flowing streams using immobilized antimicrobials. It is envisioned that the materials resulting from this effort will be suitable for deployment in packed beds for use in flowing air and water streams, and as surface coating materials for control of microbial populations on solids, and in air through passive contact. For the Phase I effort, packed beds of immobilized antimicrobials will be studied for the control of endotoxin and microorganisms in aqueous streams. The potentiation of chemical disinfection will also be investigated.

POTENTIAL COMMERCIAL APPLICATIONS

The materials for improved control of the growth of microorganisms which originate from this work can be applied in a broad variety of commercial applications, including: food processing and preparation, production of pharmaceuticals, water purification for semiconductor fabrication, and use for general household hygiene.

NAME AND ADDRESS OF PRINCIPAL INVESTIGATOR

James R. Akse, Ph.D.
Umpqua Research Company
P.O. Box 609
Myrtle Creek , OR 97457

NAME AND ADDRESS OF OFFEROR

Umpqua Research Company
P.O. Box 609
Myrtle Creek , OR 97457