Form 9.B Project Summary

Chron: 971735

Proposal Number: 09.02-1100

Project Title: Metabolite/Chemical Monitoring Using Molecular Imprint (MI) Technology

Technical Abstract (Limit 200 words)

Systems & Processes Engineering Corporation (SPEC) and Dr. J.P. Chambers of University of Texas at San Antonio propose to use molecular imprinting (MI) technology to fabricate artificial receptors for the detection of mechanistic biomarkers/chemicals. The MI technology will provide a means of developing receptors for metabolic/chemical biomarkers which currently do not exist. The need for a metabolite/chemical measurement system is critical to assessing animal or human physiology and growth in space environments. A number of protease enzymes and metabolites have been used to evaluate mechanistic responses to various physiological and environmental stresses, and growth stimulates, by immunological and immunoassay methods. However, for a number mechanistic biomarkers, no biochemical sensing/receptor components are available for biosensing applications. Furthermore, with existing sensing elements including enzymes, antibodies and lectins, requirements such as stability cannot be guaranteed. In Phase I, SPEC and Dr. Chambers propose to develop and demonstrate the MI technology for biosensor detection of a candidate biomarker of interest to NASA. In Phase II, SPEC will proceed to develop, construct and fabricate a prototype MI biosensor for biomarkers/chemicals

Potential Commercial Applications (Limit 200 words)

The development of compact, stable biosensors based on MI receptors has significant commercial applications as home diagnostic devices, medical research tools, food processing monitors, clinical instruments and environmental detectors as well as for NASA and the Department of Defense. In addition to its use for biomarkers/chemicals in humans and animals, the MI biosensor can be used to detect toxins, dangerous chemicals, and hazardous environmental agents. MI devices could significantly impact on the projected half-billion dollar market for biosensors in the year 2000.

Name and Address of Principal Investigator (Name,

Organization Name, Mail Address, City/State/Zip)

Robert C. Chin, Ph.D.

Systems & Processes Engineering Corp.

401 Camp Craft Road

Austin , TX 78746-6558

Name and Address of Offeror (Firm Name, Mail Address,

City/State/Zip)

Jim McNeal

Systems & Processes Engineering Corp.

401 Camp Craft Road

Austin , TX 78746-6558