NASA 1996 SBIR Phase I


PROPOSAL NUMBER : 96-1 16.04-3800

PROJECT TITLE : MINIMALLY INVASIVE CARDIOVASCULAR PRESSURE MEASUREMENT DEVICE

TECHNICAL ABSTRACT (LIMIT 200 WORDS)

The measurement of cardiovascular pressure is critical to the assessment of cardiovascular performance and for assessing degradation in performance resulting from long-term exposure to microgravity. Many of the key pressure measurements of interest, such as left-ventricular end-diastolic pressure, presently require cardiac catheterization. This is a highly invasive procedure and presents a risk of morbidity or death even under ideal ground conditions and is, therefore, impractical for use during a spacecraft mission. Consequently, there is a need for a minimally invasive pressure measurement device which can provide these measurements in a safe and effective way. Creare proposes to develop such an instrument based on the ultrasonic interrogation of transpulmonary encapsulated microbubbles (EMBs) currently gaining favor as echocontrast agents for routine clinical use. In a steady-state experiment, Creare has preliminary data illustrating the resonant behavior of the EMBs and analytical results which show the effect of the external pressure on the resonant characteristics. In the proposed Phase I effort, Creare will demonstrate the technique in a dynamic system with cyclic variations in ambient pressure. In Phase II, we will extend the concept to the development of a stand-alone instrument which can serve as a prototype for a spacecraft-based instrument, more extensive in vitro experiments and in vivo experiments.
POTENTIAL COMMERCIAL APPLICATIONS
In addition to the targeted use in space, the proposed instrument will have significant ground-based commercial application. It can be used for the diagnosis and assessment of atheroschlerotic lesions and congestive heart failure. It will provide a very significant improvement over current techniques which rely on arterial and left-ventricular catheterization. Patient risk will be vastly reduced, as will costs.
NAME AND ADDRESS OF PRINCIPAL INVESTIGATOR
Dr. Patrick Magari
Creare Incorported
PO Box 71
Hanover NH 03755
NAME AND ADDRESS OF OFFEROR
Crare Incorported
PO Box 7
Hanover NH 03755