NASA SBIR 2012 Solicitation


PROPOSAL NUMBER: 12-2 H12.05-8845
SUBTOPIC TITLE: In-Flight Biological Sample Analysis
PROPOSAL TITLE: Low Gravity Drug Stability Analyzer

SMALL BUSINESS CONCERN (Firm Name, Mail Address, City/State/Zip, Phone)
Real-Time Analyzers, Inc.
362 Industrial Park Road (#8)
Middletown, CT 06457 - 1548
(860) 635-9800

PRINCIPAL INVESTIGATOR/PROJECT MANAGER (Name, E-mail, Mail Address, City/State/Zip, Phone)
Stuart Farquharson
362 Industrial Park Road (#8)
Middletown, CT 06457 - 1548
(860) 635-9800 Extension :230

CORPORATE/BUSINESS OFFICIAL (Name, E-mail, Mail Address, City/State/Zip, Phone)
Stuart Farquharson
362 Industrial Park Road (#8)
Middletown, CT 06457 - 1548
(860) 635-9800 Extension :230

Estimated Technology Readiness Level (TRL) at beginning and end of contract:
Begin: 3
End: 7

Technology Available (TAV) Subtopics
In-Flight Biological Sample Analysis is a Technology Available (TAV) subtopic that includes NASA Intellectual Property (IP). Do you plan to use the NASA IP under the award?

TECHNICAL ABSTRACT (Limit 2000 characters, approximately 200 words)
The goal of this proposed program through Phase III is to build a space-worthy Drug Stability Analyzer that can determine the extent of drug degradation. It will be able to monitor the drug active pharmaceutical ingredient (API) and its degradation product concentrations as a function of time, as well as determine if a drug is suitable for use. This will be accomplished by designing and building a rugged, small, low mass, low power, easy to use analyzer that can identify and quantify API and degradation products with little or no sample handling in 1 minute. Feasibility was successfully demonstrated during Phase I by measuring acetaminophen, azithromycin, epinephrine, lidocaine, and their degradation products in mixtures and during reaction with a 1-4% limit of detection. The API's were also successfully measured in commercial products. During the Phase II program a prototype Drug Stability Analyzer, suitable for space deployment will be built and used to measure the degradants of all the ISS medical kit drugs (>100) with an accuracy goal of 2% and a precision goal of 1% within 1 minute. The Drug Stability Analyzer will be transitioned from a TRL 3 to a 7 (ground tested).

POTENTIAL NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
The proposed Drug Stability Analyzer is specifically being designed to monitor degradation of pharmaceutical drugs that are used by astronauts, so that drug types, formulations, and packaging can be improved, and supplies can be selected to match mission length. It will also have the capability of determining if a drug is suitable at the time of use (effective and safe).

POTENTIAL NON-NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
Approximately 3000 medication errors occur each year due mostly to administering incorrect drugs or doses. Pharmacies are considered the last line of defense and to minimize such errors the Drug Compounding Safety Bill will soon become law. The Drug Stability Analyzer will have great value to pharmacies with its ability to confirm drug identity and dosage in 10 seconds as it is given to the customer. The analyzer will also have great value in its ability to identify counterfeit (fake) drugs. According to the World Health Organization, ~10% of all drugs sold worldwide are counterfeit (largely through the internet), and have resulted in 200,000 deaths per year. Many of the drugs sold in the US are manufactured oversees, and in recent years the standard supply chains have also been compromised.

TECHNOLOGY TAXONOMY MAPPING (NASA's technology taxonomy has been developed by the SBIR-STTR program to disseminate awareness of proposed and awarded R/R&D in the agency. It is a listing of over 100 technologies, sorted into broad categories, of interest to NASA.)
Analytical Instruments (Solid, Liquid, Gas, Plasma, Energy; see also Sensors)
Health Monitoring & Sensing (see also Sensors)
Lifetime Testing

Form Generated on 03-04-14 13:38