NASA STTR 2011 Solicitation

FORM B - PROPOSAL SUMMARY


PROPOSAL NUMBER: 11-1 T1.02-9940
RESEARCH SUBTOPIC TITLE: Commodity Based Technologies
PROPOSAL TITLE: An Electrochemical, Point-of-Care Detector for Reagent-free, In-situ Diagnostics of Pathogens

SMALL BUSINESS CONCERN (SBC): RESEARCH INSTITUTION (RI):
NAME: CFD Research Corporation NAME: Marilyn Haapapuro
STREET: 215 Wynn Drive, 5th Floor STREET: 1400 Townsend Drive
CITY: Huntsville CITY: Houghton
STATE/ZIP: AL  35805 - 1926 STATE/ZIP: MI  49931 - 1295
PHONE: (256) 726-4800 PHONE: (906) 487-1977

PRINCIPAL INVESTIGATOR/PROJECT MANAGER (Name, E-mail, Mail Address, City/State/Zip, Phone)
Jianjun Wei
proposals-contracts@cfdrc.com
215 Wynn Drive, NW, Flr 5
Huntsville, AL 35805 - 1926
(256) 327-0672

Estimated Technology Readiness Level (TRL) at beginning and end of contract:
Begin: 1
End: 3

TECHNICAL ABSTRACT (Limit 2000 characters, approximately 200 words)
For long-term exploratory space travel, there will be a critical need for in-situ diagnosis and assessment of biological specimens from symptomatic astronauts, especially, disease pathogens (virus, bacterium, or fungus) and microbial contaminants. Hence, a real-time, non-culture-based microbial detection, identification and quantification system for on-flight monitoring and evaluation of pathogens from astronauts, or the space environment, is strongly desired. The success of such diagnostic tasks critically depends upon the degree of automation and reliability of such trace level detection. To meet this need, we propose to develop a novel miniaturized, point-of-care (POC) detector for reagent-free, no-culturing, in-situ diagnostics of disease pathogens. The envisioned device will be compact, lightweight, fully integrated and automated (requiring minimum human intervention), and highly cost-effective and power-efficient. In Phase I, we will develop a new type of electrochemical molecules and fabricate solid electrode-based probe for in-vitro demonstration of accurate and effective signal transduction of selective binding of pathogenic cells to the electrode as proof-of-principle. In Phase II, the electrode probe will be optimized to increase specificity, sensitivity, stability, and the response to regular biological samples. Finally, the sensor will be integrated with a compact handheld instrument for data collection, analysis and processing and interfacing with existing NASA space instrumentation for both terrestrial and microgravity environments evaluation.

POTENTIAL NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
The end product of the proposed STTR effort will be a first-of-a-kind, commercially available, compact, low-cost, integrated disease pathogen analysis device without need of cell-culturing. NASA will have a handheld, easy-to-use electrochemical pathogen detector that can be easily integrated with existing astrobiological instrumentation and/or emerging smart biomedical system to keep track of astronaut health and space environment during planetary exploration. In addition, the same device can be adapted and used in other applications such as, life discovery on other planets, pharmacotherapy environment monitoring, and space biology experiments.

POTENTIAL NON-NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
The platform developed in this effort will provide the technological backbone to develop a new type of electrochemical sensor or diagnostic technology and no-cell-culturing-based pathogen detection for a variety of applications in healthcare, life sciences, hospital and health site monitoring. This platform will enable the creation of in-situ analytical tools for the preparation, detection, and analysis of low level pathogens obtained from biological fluid and/or water samples. It may find use in drug discovery and the study of human diseases, clinical and preclinical diagnosis, as well as in the areas of cellular biology, microbiology, and homeland security. Total market estimates exceed several hundred million dollars.

TECHNOLOGY TAXONOMY MAPPING (NASA's technology taxonomy has been developed by the SBIR-STTR program to disseminate awareness of proposed and awarded R/R&D in the agency. It is a listing of over 100 technologies, sorted into broad categories, of interest to NASA.)
Biological (see also Biological Health/Life Support)
Biological Signature (i.e., Signs Of Life)
Chemical/Environmental (see also Biological Health/Life Support)
Health Monitoring & Sensing (see also Sensors)
Nanomaterials
Organics/Biomaterials/Hybrids
Physiological/Psychological Countermeasures
Smart/Multifunctional Materials


Form Generated on 11-22-11 13:44