NASA SBIR 2011 Solicitation


PROPOSAL NUMBER: 11-2 X13.01-9228
SUBTOPIC TITLE: Smart Phone Driven Blood-Based Diagnostics
PROPOSAL TITLE: Cell Phone-based Lateral Flow Assay for Blood Biomarker Detection

SMALL BUSINESS CONCERN (Firm Name, Mail Address, City/State/Zip, Phone)
Intelligent Optical Systems, Inc.
2520 West 237th Street
Torrance, CA 90505 - 5217
(424) 263-6300

PRINCIPAL INVESTIGATOR/PROJECT MANAGER (Name, E-mail, Mail Address, City/State/Zip, Phone)
Henry Lin
2520 West 237th Street
Torrance, CA 90505 - 5217
(424) 263-6344

Estimated Technology Readiness Level (TRL) at beginning and end of contract:
Begin: 5
End: 7

TECHNICAL ABSTRACT (Limit 2000 characters, approximately 200 words)
The ability to integrate a sensor platform with a cell phone for health monitoring and disease diagnosis for astronauts in space has the potential to be cost effective and space saving. In this proposal, Intelligent Optical Systems (IOS) builds upon its expertise in lateral flow test strip (LFTS) assays by integrating an LFTS with a cell phone for the quantitative measurement of blood-based biomarkers. Our innovative and extremely cost-effective multi-analyte LFTS approach is eminently suited for space travel. Taking advantage of the built-in flash and high resolution camera, in Phase I we have modified a commercially available cell phone with optical filters, lenses, a UV LED excitation source, and a cassette holder for LFTS image capture. In Phase II, we will expand the capability of cell phone-based LFTS for an antibody-antigen sandwich binding assay to include blood gas measurements by developing sensitive indicator films to be integrated with our cell phone-based detector. Furthermore, we will develop cell phone-based software for on-cell phone detection and data processing with an expanded panel of biomarkers, advancing the TRL from 5 to 7.

POTENTIAL NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
Future space missions will require prolonged stays of crew members onboard space stations, and on other spacecraft for journeys to other planets. Increasingly complex space missions will also require monitoring the health status of astronauts, preferably in a point-of-care apparatus that is compact and simple. The IOS system will enable NASA to monitor the health status of crew members by means of simple blood-based biomarker detection. A lateral flow test strip will be integrated with a cell phone into a simple and compact blood biomarker detection platform. This platform will gather diagnostic information in the absence of medically trained personnel, and can also monitor the health of aircraft pilots, cabin crews, passengers, and others in aeronautics-related occupations.

POTENTIAL NON-NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
A cell phone-based serum biomarker detection platform will be cost-effective and compact not only for space exploration; it will also benefit the overall healthcare industry. Cell phones are becoming increasingly prevalent all over the world, with approximately five billion subscribers worldwide, and in the U.S. approximately one in three adults owns a smart phone. The ability to integrate a simple LFTS assay with a cell phone will enable healthcare providers to perform blood tests for many diseases on a wide population, including populations in remote areas where healthcare facilities are sparse. Such a platform can have a major impact in developing countries where a simple cell phone can be converted into a blood marker detection platform, avoiding the cost of acquiring dedicated medical equipment; furthermore, this point-of-care device improves the probability of early detection, yielding additional savings in overall healthcare cost. Military field medicine will also benefit from the availability of a versatile handheld medical blood testing device that takes advantage of the ubiquitous mobile phone to minimize weight and power requirements.

TECHNOLOGY TAXONOMY MAPPING (NASA's technology taxonomy has been developed by the SBIR-STTR program to disseminate awareness of proposed and awarded R/R&D in the agency. It is a listing of over 100 technologies, sorted into broad categories, of interest to NASA.)
Biological (see also Biological Health/Life Support)
Health Monitoring & Sensing (see also Sensors)

Form Generated on 09-03-12 17:04