NASA SBIR 02-1 Solicitation


PROPOSAL NUMBER:02- B2.03-8793 (For NASA Use Only - Chron: 023206 )
SUBTOPIC TITLE: Understanding and Utilizing Gravitational Effects on Molecular Biology and for Medical Applications
PROPOSAL TITLE: Organic Thin Film Transistor for Microfluidic Flow Cytometry

SMALL BUSINESS CONCERN (Firm Name, Mail Address, City/State/Zip, Phone)
Agave BioSystems Inc
401 E. State St..
Ithaca , NY   14850 - 0000
(607 ) 272 - 0002

PRINCIPAL INVESTIGATOR/PROJECT MANAGER (Name, E-mail, Mail Address, City/State/Zip, Phone)
Joel Tabb
401 E. State St..
Ithaca , NY   14850 - 0000
(512 ) 671 - 1369

Agave BioSystems proposes to develop and demonstrate an innovative Organic Thin Film Transistor (OTFT) to detect cell characteristics without the need for cell labeling for use in microfluidic flow cytometers. This sensor would be able to detect count all cells, whether the cells are fluorescently labeled or not. This device would easily be able to detect the presence of cells within the channel as well as give information about the cell size and even the DNA content or intactness of the cell. The fact that cells will not need to be fluorescently labeled for detection is one of the major advantages of this device, since it can be used to measure live, unperturbed cells. Microfabrication of the OTFTs and microfluidic components will allow development of inexpensive, self-contained, disposable, high-throughput devices for screening of combinatorial chemical, biochemical or biological libraries. Assisting in this project will be Prof. George Malliaras of the Department of Materials Science and Engineering of Cornell University and Dr. James F. Leary, Professor and Director of the Molecular Cytometry Unit at UTMB-Galveston.

Because the fluidic components of these microfabricated devices would be inexpensive to generate, they would be disposable, making them ideal for a number of laboratory and clinical settings, especially those involving the detection or sorting of infectious or otherwise hazardous samples. The potential for development of high-throughput devices would allow utilization in screening of combinatorial chemical, biochemical or biological libraries.

Current systems are not well suited for use in low gravity environments or impose a significant cost in payload size and weight. The proposed device would be small, low-weight, low power, self-contained, and disposable making it be ideal for use in low gravity environments.

Form Printed on 09-05-02 10:10